Endocrine Abstracts

Introduction: Erdheim-Chester disease is a rare form of non-Langerhans’ cell histiocytosis characterised by foamy histiocyte infiltration with multi-systemic manifestations. Roughly 550 cases have been described in the literature, most frequently affecting men aged 40-60. Bony pain is the most common symptom, resulting from osteosclerotic lesions of the long bones of the lower limbs. Extra-skeletal manifestations are varied and include diabetes insipidus resulting from pi...

During early life, the majority of cardiomyocytes exit the cell cycle and undergo terminal differentiation, becoming binucleated. This establishes the number of cardiomyocytes for the remainder of the lifetime, with subsequent consequences for cardiac resilience in adulthood. Activation of the glucocorticoid receptor (GR) is important for heart maturation: fetal mice lacking GR in cardiomyocytes (SMGRKO) show structural and functional cardiac immaturity. Young adult male and f...

Caloric restriction (CR) is a nutritional intervention that reduces the risk of age-related diseases in numerous species, including humans. CR’s metabolic effects, including decreased fat mass and improved insulin sensitivity, play an important role in its broader health benefits, yet many aspects of the CR response remain poorly understood. In particular, sex differences in metabolic function are increasingly well recognised, but the extent and basis of sex differences i...